payment-ready until 2026-10-02
FDA drug-approval catalyst change stream for US-listed biotechs: every state change of every catalyst we track — each PDUFA date as it is set, extended and resolved — with the real outcome (approval or CRL), the SEC filing quote and its EDGAR source. A superset of the upcoming calendar, as a since-cursor delta feed. Date accuracy AND coverage are published free at GET /v1/accuracy — audit before you pay. Flat price per request.
Pay from $0.02 to $0.05 per request in USDC on Base / Solana, settled onchain via the x402 protocol, no signup, no API key needed.
measured since 2026-06-23 (start of our harvest window) · $1.94 all-time · settled via coinbase
VERDICT
ranking generation 3solid 83/100 #178 of 320 in Data by measured score
What the score read on this service: status online, 100% uptime 30d, 870ms response p95, x402 compliance 14 of 14, $0.02 price against the category, on-chain traction measured. Each of those is measured, and each is published in full below.
The score comes from our own monitoring, never from reviews, operator claims, or a language model: reliability, x402 compliance, price against the category, a deterministic risk flag, and a small on-chain traction term, weighted by ranking generation 3. It is not placement anyone can buy: the paid verify tier is reported beside it and is not one of its inputs. Every component below stays published and read-only.
It is a score inside Data, and only there: price and speed are scored against the whole category field, every listing in it that carries no danger flag, the scored service included, which here means 320 listings, this one among them. That set is wider than the 320 the position above is counted against, because a listing we have measured too little of to rank still sits in the field the price and the speed are normalized over. The same service in a different field would read differently. The same engine answers GET /api/v1/best, and asked for a different pool (the whole directory, or another filter) it returns a different number for this service under this same ranking generation. Neither is more correct: they answer different questions, and the methodology states which is which.
Bands on the 0 to 100 measured score: strong at 93 and above, solid from 75, mixed from 55, weak below 55. Price and speed are scored against the whole category field, every listing in it that carries no danger flag, the scored service included, so the score places a service in its own field.
ALTERNATIVES IN DATA
Other Data services in this directory, ordered by the same measured score. The figures are ours: 30-day uptime from our own probes, 30-day settlement volume read on-chain (a conservative undercount, and null where we cannot measure it, never a zero).
| SERVICE | BAND | SCORE | UPTIME 30D | VOL 30D |
|---|---|---|---|---|
| Lemon Toolshed | strong | 97 | 100% | --- |
| Agent Web Access | strong | 97 | 99.7% | --- |
| longwatch | strong | 97 | 100% | --- |
| StableEnrich | strong | 95 | 100% | $2.0k |
| SniperX•x402 | strong | 95 | 100% | $273.81 |
ASSESSMENT
updated 2h agoThe parts the verdict above is computed from, each with its proof. Click any chip. Measured values stay read-only; unknown is honest, and an unknown is never counted as a zero.
reliability 100%
- uptime 24h
- 100%
- uptime 7d
- 100%
- uptime 30d
- 100%
- uptime 90d
- 100%
- response p95
- 870ms
- avg response
- 644ms
- total checks
- 2,699
Measured on the unpaid 402 handshake, not the paid call. A service can 402 correctly and still fail after payment.
compliance A (14/14)
14 of 14 x402 conformance checks pass. Full checklist below.
price $0.02 to $0.05 (p75 in Data)
- price (min)
- $0.02
- price (max)
- $0.05
- category percentile (min)
- p75 in Data
- category percentile (max)
- p59 in Data
- endpoints / prices
- 2 / 2
- model
- tiered
- stability
- 100%
risk clean
No deterministic risk flag. Risk fires only on an exact blocklist match, or a reserved-brand name with a mismatched verified payTo. Never from low uptime, a high price, or a model guess.
- domain age
- -
- registrar
- -
- hosting
- custom
- domain created
- ---
Identity facts, not a risk score.
traction $0.67 30d · 12 buyers
- volume 30d
- $0.67
- buyers 30d
- 12
- settlements 30d
- 23
- measured since
- 2026-06-23 (start of our harvest window)
- last settlement
- 2026-09-24
- top buyer share
- 52% of 30d volume
- trend 7d vs 30d
- 0.13x the 30d daily rate
- networks
- eip155:8453, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdpKuc147dw2N9d
- volume all-time
- $1.94
- settlements all-time
- 67
- median settlement 30d
- $0.02
- max settlement 30d
- $0.05
- settled via
- coinbase ($0.67, 23 tx)
Conservative undercount: only USDC settlements via facilitators we measure are counted. A measured floor, not an estimate.
Top buyer share is a concentration signal, not part of the ranking score.
CHANGES
10 in 30dPayout, price, and schema changes detected on this service's x402 wire. A payout rotation at an unchanged price shows up here even when nothing else moves. Full feed at /changes.
changes schema changed 47h ago (10 in 30d)
schema changed · 47h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema removed GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}
schema added GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}
schema changed · 13d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
schema removed GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema added GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema changed · 17d ago
endpoint added GET /v1/events
schema added GET /v1/events exact eip155:8453 0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913 USDC 2 300 {"name":"USD Coin","version":"2"}
schema added GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
schema changed · 19d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
schema changed · 19d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema changed · 19d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
schema changed · 19d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema changed · 20d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema changed · 21d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}
schema changed · 21d ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}
WHAT IT DOES
ai-derivedNo AI synthesis has been produced for this service yet.
ENDPOINTS
| METHOD | PATH | DESCRIPTION | PRICE | NETWORK | ASSET | 402 CHANNEL |
|---|---|---|---|---|---|---|
| GET | /v1/catalysts/upcoming | $0.02 | Base/Solana | USDC | header | |
| GET | /v1/events | $0.05 | Base/Solana | USDC | header |
REQUEST / RESPONSE EXAMPLE
An unpaid request to GET /v1/catalysts/upcoming returns HTTP 402 with the payment terms. Settle onchain via your facilitator, then retry with the X-Payment header.
curl -i 'https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming'
// 402 response (captured by monitor) · 2 payloads · click to expand
[
{
"error": "Payment required",
"accepts": [
{
"asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
"extra": {
"name": "USD Coin",
"version": "2"
},
"payTo": "0xcD8975137D48ED9bfD1C299a62c01420B860070d",
"amount": "50000",
"scheme": "exact",
"network": "eip155:8453",
"maxTimeoutSeconds": 300
},
{
"asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
"extra": {
"feePayer": "Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"
},
"payTo": "3gM4YDDPAi7w1di7rHAAaHc5T1tR7NRXzLWzPPN4ZRaM",
"amount": "50000",
"scheme": "exact",
"network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
"maxTimeoutSeconds": 300
}
],
"resource": {
"url": "https://api.biotechcatalystsentinel.com/v1/events",
"mimeType": "application/json",
"description": "FDA drug-approval catalyst change stream for US-listed biotechs: every state change of every tracked catalyst — each PDUFA date as set, extended and resolved — with the real outcome (approval or CRL), the SEC filing quote and its EDGAR source, as a since-cursor delta feed. Use when you mirror the calendar and need date changes and outcomes as they land, not a snapshot. Accuracy AND coverage are free at GET /v1/accuracy. Flat price per request."
},
"extensions": {
"bazaar": {
"info": {
"input": {
"type": "http",
"method": "GET",
"queryParams": {
"limit": 100,
"since": 0
}
},
"output": {
"type": "json",
"example": {
"data": [
{
"ticker": "XSMPL",
"applied": true,
"company": "Sample Therapeutics, Inc.",
"outcome": null,
"tickers": [
"XSMPL",
"XPRTN"
],
"event_id": 990101,
"filed_at": "2025-11-03",
"new_date": "2026-04-18",
"accession": "0009999001-25-000090",
"authority": "llm_high",
"drug_name": "SAMPLIMAB",
"confidence": "high",
"delta_days": null,
"event_type": "new_date_assigned",
"indication": "sample indication (moderate-to-severe examplitis)",
"prior_date": null,
"source_url": "https://www.sec.gov/Archives/edgar/data/9999001/000999900125000090/0009999001-25-000090-index.htm",
"catalyst_id": 990001,
"detected_at": "2025-11-03T13:41:09.000000+00:00",
"merged_into": null,
"date_changed": true,
"days_to_date": null,
"source_quote": "The FDA has assigned a PDUFA target action date of April 18, 2026 for SAMPLIMAB. [FICTIONAL SAMPLE — not a real filing sentence]",
"date_confidence": "confirmed",
"new_date_upcoming": false,
"application_number": "BLA999901"
}
],
"meta": {
"limit": 100,
"total": 1,
"has_more": false,
"next_since": 990106
}
}
}
},
"schema": {
"type": "object",
"$schema": "https://json-schema.org/draft/2020-12/schema",
"required": [
"input"
],
"properties": {
"input": {
"type": "object",
"required": [
"type",
"method"
],
"properties": {
"type": {
"type": "string",
"const": "http"
},
"method": {
"enum": [
"GET",
"HEAD",
"DELETE"
],
"type": "string"
},
"queryParams": {
"type": "object",
"required": [],
"properties": {
"limit": {
"type": "integer",
"default": 100,
"maximum": 500,
"minimum": 1,
"description": "Maximum number of events to return (1-500; default 100)."
},
"since": {
"type": "integer",
"minimum": 0,
"description": "Cursor: return only events with an event_id greater than this (0 = from the start). Pass the last event_id you saw to page forward."
},
"ticker": {
"type": "string",
"pattern": "^\\S+$",
"maxLength": 12,
"minLength": 1,
"description": "Optional server-side filter: only events whose record is filed by this ticker's issuer or exposes it as a co-filer in tickers[] (case-insensitive). Composes with since — limit counts matched events, so a filtered backlog drains without gaps. Unknown ticker returns an empty 200. Does not change the price."
}
}
}
},
"additionalProperties": false
},
"output": {
"type": "object",
"required": [
"type"
],
"properties": {
"type": {
"type": "string"
},
"example": {
"type": "object",
"properties": {
"data": {
"type": "array",
"items": {
"type": "object",
"required": [
"event_id",
"catalyst_id",
"event_type"
],
"properties": {
"ticker": {
"type": [
"string",
"null"
]
},
"applied": {
"type": "boolean"
},
"company": {
"type": [
"string",
"null"
]
},
"outcome": {
"enum": [
"approved",
"tentative",
"crl",
"none_found",
null
],
"type": [
"string",
"null"
]
},
"tickers": {
"type": "array",
"items": {
"type": "string"
}
},
"event_id": {
"type": "integer"
},
"filed_at": {
"type": [
"string",
"null"
]
},
"new_date": {
"type": [
"string",
"null"
]
},
"accession": {
"type": [
"string",
"null"
]
},
"authority": {
"enum": [
"human_lock",
"llm_high",
"regex",
"llm_medium",
"llm_low",
null
],
"type": [
"string",
"null"
]
},
"drug_name": {
"type": [
"string",
"null"
]
},
"confidence": {
"enum": [
"high",
"medium",
"low",
null
],
"type": [
"string",
"null"
]
},
"delta_days": {
"type": [
"integer",
"null"
]
},
"event_type": {
"enum": [
"new_date_assigned",
"date_extension",
"decision_outcome",
"retracted",
"restored",
"corrected"
],
"type": "string"
},
"indication": {
"type": [
"string",
"null"
]
},
"prior_date": {
"type": [
"string",
"null"
]
},
"source_url": {
"type": [
"string",
"null"
]
},
"catalyst_id": {
"type": "integer"
},
"detected_at": {
"type": [
"string",
"null"
]
},
"merged_into": {
"type": [
"integer",
"null"
]
},
"date_changed": {
"type": "boolean"
},
"days_to_date": {
"type": [
"integer",
"null"
]
},
"source_quote": {
"type": [
"string",
"null"
]
},
"date_confidence": {
"enum": [
"confirmed",
"reported",
"estimated",
null
],
"type": [
"string",
"null"
]
},
"new_date_upcoming": {
"type": "boolean"
},
"application_number": {
"type": [
"string",
"null"
]
}
}
},
"description": "One row per state change, oldest-first while draining a `since` cursor. `tickers` lists every co-filer exposed to the decision."
},
"meta": {
"type": "object",
"description": "Result metadata, e.g. total count."
}
}
}
}
}
}
}
}
},
"x402Version": 2
},
{
"error": "Payment required",
"accepts": [
{
"asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
"extra": {
"name": "USD Coin",
"version": "2"
},
"payTo": "0xcD8975137D48ED9bfD1C299a62c01420B860070d",
"amount": "20000",
"scheme": "exact",
"network": "eip155:8453",
"maxTimeoutSeconds": 300
},
{
"asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
"extra": {
"feePayer": "Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"
},
"payTo": "3gM4YDDPAi7w1di7rHAAaHc5T1tR7NRXzLWzPPN4ZRaM",
"amount": "20000",
"scheme": "exact",
"network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
"maxTimeoutSeconds": 300
}
],
"resource": {
"url": "https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming",
"mimeType": "application/json",
"description": "Upcoming FDA drug-approval (PDUFA) decision dates for US-listed biotechs — a forward catalyst calendar from primary SEC 8-K/6-K filings, every date grounded in a verbatim filing quote, cited to its EDGAR accession and later scored against the actual FDA decision. Use when you need the next 1-365 days of binary FDA events, whole feed or one ticker. Verify accuracy AND coverage free at GET /v1/accuracy before you pay. Flat price per request."
},
"extensions": {
"bazaar": {
"info": {
"input": {
"type": "http",
"method": "GET",
"queryParams": {
"limit": 200,
"within_days": 365
}
},
"output": {
"type": "json",
"example": {
"data": [
{
"cik": "0009999001",
"stage": "set",
"ticker": "XSMPL",
"company": "Sample Therapeutics, Inc.",
"tickers": [
"XSMPL",
"XPRTN"
],
"age_days": 12,
"authority": "llm_high",
"drug_name": "SAMPLIMAB",
"confidence": "high",
"indication": "sample indication (moderate-to-severe examplitis)",
"pdufa_date": "2026-11-15",
"source_url": "https://www.sec.gov/Archives/edgar/data/9999001/000999900126000001/0009999001-26-000001-index.htm",
"catalyst_id": 990001,
"last_updated": "2026-07-20T14:02:11.000000+00:00",
"source_quote": "The FDA has set a Prescription Drug User Fee Act (PDUFA) target action date of November 15, 2026 for SAMPLIMAB. [FICTIONAL SAMPLE — not a real filing sentence]",
"date_confidence": "confirmed",
"source_accession": "0009999001-26-000001",
"application_number": "BLA999901"
}
],
"meta": {
"limit": 200,
"total": 1,
"has_more": null,
"next_since": null
}
}
}
},
"schema": {
"type": "object",
"$schema": "https://json-schema.org/draft/2020-12/schema",
"required": [
"input"
],
"properties": {
"input": {
"type": "object",
"required": [
"type",
"method"
],
"properties": {
"type": {
"type": "string",
"const": "http"
},
"method": {
"enum": [
"GET",
"HEAD",
"DELETE"
],
"type": "string"
},
"queryParams": {
"type": "object",
"required": [],
"properties": {
"limit": {
"type": "integer",
"default": 200,
"maximum": 500,
"minimum": 1,
"description": "Maximum number of catalysts to return (1-500; default 200)."
},
"ticker": {
"type": "string",
"pattern": "^\\S+$",
"maxLength": 12,
"minLength": 1,
"description": "Optional server-side filter: only records filed by this ticker's issuer or exposing it as a co-filer in tickers[] (case-insensitive; the same membership the free /v1/coverage counts). Unknown ticker returns an empty 200. Omit for the whole feed. Does not change the price."
},
"within_days": {
"type": "integer",
"default": 365,
"maximum": 365,
"minimum": 1,
"description": "Only return catalysts whose PDUFA date falls within this many days from today (1-365; default 365)."
}
}
}
},
"additionalProperties": false
},
"output": {
"type": "object",
"required": [
"type"
],
"properties": {
"type": {
"type": "string"
},
"example": {
"type": "object",
"properties": {
"data": {
"type": "array",
"items": {
"type": "object",
"required": [
"catalyst_id",
"stage"
],
"properties": {
"cik": {
"type": [
"string",
"null"
]
},
"stage": {
"enum": [
"set",
"extended",
"resolved",
"crl"
],
"type": "string"
},
"ticker": {
"type": [
"string",
"null"
]
},
"company": {
"type": [
"string",
"null"
]
},
"tickers": {
"type": "array",
"items": {
"type": "string"
}
},
"age_days": {
"type": [
"integer",
"null"
]
},
"authority": {
"enum": [
"human_lock",
"llm_high",
"regex",
"llm_medium",
"llm_low",
null
],
"type": [
"string",
"null"
]
},
"drug_name": {
"type": [
"string",
"null"
]
},
"confidence": {
"enum": [
"high",
"medium",
"low",
null
],
"type": [
"string",
"null"
]
},
"indication": {
"type": [
"string",
"null"
]
},
"pdufa_date": {
"type": [
"string",
"null"
]
},
"source_url": {
"type": [
"string",
"null"
]
},
"catalyst_id": {
"type": "integer"
},
"last_updated": {
"type": [
"string",
"null"
]
},
"source_quote": {
"type": [
"string",
"null"
]
},
"date_confidence": {
"enum": [
"confirmed",
"reported",
"estimated",
null
],
"type": [
"string",
"null"
]
},
"source_accession": {
"type": [
"string",
"null"
]
},
"application_number": {
"type": [
"string",
"null"
]
}
}
},
"description": "One row per upcoming FDA decision. One decision is ONE row even when several public companies file on it (sponsor, originator, royalty holder) — filter on the `tickers` array, not the single `ticker`, or you will miss catalysts a partner is exposed to."
},
"meta": {
"type": "object",
"description": "Result metadata, e.g. total count."
}
}
}
}
}
}
}
}
},
"x402Version": 2
}
] OVER TIME
All charts use the 90d selector; each series spans only the dates it has data for. Every series is also served as JSON at /api/v1/services/biotech-catalyst-sentinel/price, /scores, /volume and /buyers. On-chain volume and distinct buyers are measured over the service's settlement address and are a conservative undercount (only settlements that reach a measured facilitator are counted). The on-chain series roll up hourly, so the latest day can be up to about an hour behind; distinct buyers are counted per payout address, so a service that settles to more than one address is an upper bound.
Median across 2 endpoints. Use the selector to isolate one.
checklist grew 11->14 on 2026-07-28; a step here is a metric change, not a regression
Measured site and economics pillars from the assessment history, so the latest value shown elsewhere on this page reads as a point on a trend rather than a permanent state.
COMPLIANCE
14/14 checks pass · grade Alast 402 captured 2026-09-23 · last up 2026-09-25
- 402 payload captured
- accepts[] array present
- payTo address recoverable
- payTo at accepts[0].payTo (conformant shape)
- payTo is a valid on-chain address
- atomic price declared
- atomic price in a sane range
- asset (token) address declared
- network resolves to CAIP-2
- payment scheme declared
- served over HTTPS
- declares the current x402 version (2)
- EIP-712 domain parameters present on every EVM entry
- x402 v2 envelope delivered in the payment-required header
SITE PILLARS
- homepage reachable
- openapi doc
- pricing page
- llms.txt
- robots.txt
- terms page
recent checks (18) live · click to expand
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