●

Biotech Catalyst Sentinel

Data PAYMENT-READY

payment-ready until 2026-10-02

FDA drug-approval catalyst change stream for US-listed biotechs: every state change of every catalyst we track — each PDUFA date as it is set, extended and resolved — with the real outcome (approval or CRL), the SEC filing quote and its EDGAR source. A superset of the upcoming calendar, as a since-cursor delta feed. Date accuracy AND coverage are published free at GET /v1/accuracy — audit before you pay. Flat price per request.

Pay from $0.02 to $0.05 per request in USDC on Base / Solana, settled onchain via the x402 protocol, no signup, no API key needed.

measured since 2026-06-23 (start of our harvest window) · $1.94 all-time · settled via coinbase

BASE URL https://api.biotechcatalystsentinel.com │ WEBSITE https://biotechcatalystsentinel.com │ ENDPOINTS 2 │ NETWORK Base / Solana │ ASSET USDC │ MEMBER SINCE 2026-06-25 │ MONITORED SINCE 2026-06-25

VERDICT

ranking generation 3

solid 83/100 #179 of 320 in Data by measured score

What the score read on this service: status online, 100% uptime 30d, 870ms response p95, x402 compliance 14 of 14, $0.02 price against the category, on-chain traction measured. Each of those is measured, and each is published in full below.

The score comes from our own monitoring, never from reviews, operator claims, or a language model: reliability, x402 compliance, price against the category, a deterministic risk flag, and a small on-chain traction term, weighted by ranking generation 3. It is not placement anyone can buy: the paid verify tier is reported beside it and is not one of its inputs. Every component below stays published and read-only.

It is a score inside Data, and only there: price and speed are scored against the whole category field, every listing in it that carries no danger flag, the scored service included, which here means 320 listings, this one among them. That set is wider than the 320 the position above is counted against, because a listing we have measured too little of to rank still sits in the field the price and the speed are normalized over. The same service in a different field would read differently. The same engine answers GET /api/v1/best, and asked for a different pool (the whole directory, or another filter) it returns a different number for this service under this same ranking generation. Neither is more correct: they answer different questions, and the methodology states which is which.

Bands on the 0 to 100 measured score: strong at 93 and above, solid from 75, mixed from 55, weak below 55. Price and speed are scored against the whole category field, every listing in it that carries no danger flag, the scored service included, so the score places a service in its own field.

ALTERNATIVES IN DATA

Other Data services in this directory, ordered by the same measured score. The figures are ours: 30-day uptime from our own probes, 30-day settlement volume read on-chain (a conservative undercount, and null where we cannot measure it, never a zero).

Ranked alternative x402 services in the same category, with band, measured score, 30-day uptime and 30-day on-chain settlement volume
SERVICE	BAND	SCORE	UPTIME 30D	VOL 30D
Lemon Toolshed	strong	97	100%	---
Agent Web Access	strong	97	99.7%	---
longwatch	strong	97	100%	---
StableEnrich	strong	95	100%	$2.0k
SniperX•x402	strong	95	100%	$273.81

5 of 319 other ranked services in Data · see the whole category

ASSESSMENT

updated 51m ago

The parts the verdict above is computed from, each with its proof. Click any chip. Measured values stay read-only; unknown is honest, and an unknown is never counted as a zero.

reliability 100%

uptime 24h: 100%
uptime 7d: 100%
uptime 30d: 100%
uptime 90d: 100%
response p95: 870ms
avg response: 644ms
total checks: 2,699

Measured on the unpaid 402 handshake, not the paid call. A service can 402 correctly and still fail after payment.

compliance A (14/14)

14 of 14 x402 conformance checks pass. Full checklist below.

jump to compliance checklist

price $0.02 to $0.05 (p75 in Data)

price (min): $0.02
price (max): $0.05
category percentile (min): p75 in Data
category percentile (max): p59 in Data
endpoints / prices: 2 / 2
model: tiered
stability: 100%

risk clean

No deterministic risk flag. Risk fires only on an exact blocklist match, or a reserved-brand name with a mismatched verified payTo. Never from low uptime, a high price, or a model guess.

domain age: -
registrar: -
hosting: custom
domain created: ---

Identity facts, not a risk score.

traction $0.67 30d · 12 buyers

volume 30d: $0.67
buyers 30d: 12
settlements 30d: 23
measured since: 2026-06-23 (start of our harvest window)
last settlement: 2026-09-24
top buyer share: 52% of 30d volume
trend 7d vs 30d: 0.13x the 30d daily rate
networks: eip155:8453, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdpKuc147dw2N9d
volume all-time: $1.94
settlements all-time: 67
median settlement 30d: $0.02
max settlement 30d: $0.05
settled via: coinbase ($0.67, 23 tx)

Conservative undercount: only USDC settlements via facilitators we measure are counted. A measured floor, not an estimate.

Top buyer share is a concentration signal, not part of the ranking score.

CHANGES

10 in 30d

Payout, price, and schema changes detected on this service's x402 wire. A payout rotation at an unchanged price shows up here even when nothing else moves. Full feed at /changes.

changes schema changed 46h ago (10 in 30d)

schema changed · 46h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema removed GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}

schema added GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}

schema changed · 13d ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}

schema removed GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema added GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema changed · 17d ago

endpoint added GET /v1/events

schema added GET /v1/events exact eip155:8453 0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913 USDC 2 300 {"name":"USD Coin","version":"2"}

schema added GET /v1/events exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}

schema changed · 19d ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"D6ZhtNQ5nT9ZnTHUbqXZsTx5MH2rPFiBBggX4hY1WePM"}

schema changed · 19d ago

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}

schema changed · 19d ago

schema changed · 20d ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}

schema changed · 21d ago

see all changes for this service

WHAT IT DOES

ai-derived

No AI synthesis has been produced for this service yet.

ENDPOINTS

Service endpoints with HTTP method, path, description, pricing, and network
METHOD	PATH	DESCRIPTION	PRICE	NETWORK	ASSET	402 CHANNEL
GET	/v1/catalysts/upcoming		$0.02	Base/Solana	USDC	header
GET	/v1/events		$0.05	Base/Solana	USDC	header

2 endpoints

REQUEST / RESPONSE EXAMPLE

An unpaid request to GET /v1/catalysts/upcoming returns HTTP 402 with the payment terms. Settle onchain via your facilitator, then retry with the X-Payment header.

// request

curl -i 'https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming'

// 402 response (captured by monitor) · 2 payloads · click to expand

[
  {
    "error": "Payment required",
    "accepts": [
      {
        "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
        "extra": {
          "name": "USD Coin",
          "version": "2"
        },
        "payTo": "0xcD8975137D48ED9bfD1C299a62c01420B860070d",
        "amount": "50000",
        "scheme": "exact",
        "network": "eip155:8453",
        "maxTimeoutSeconds": 300
      },
      {
        "asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
        "extra": {
          "feePayer": "Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"
        },
        "payTo": "3gM4YDDPAi7w1di7rHAAaHc5T1tR7NRXzLWzPPN4ZRaM",
        "amount": "50000",
        "scheme": "exact",
        "network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
        "maxTimeoutSeconds": 300
      }
    ],
    "resource": {
      "url": "https://api.biotechcatalystsentinel.com/v1/events",
      "mimeType": "application/json",
      "description": "FDA drug-approval catalyst change stream for US-listed biotechs: every state change of every tracked catalyst — each PDUFA date as set, extended and resolved — with the real outcome (approval or CRL), the SEC filing quote and its EDGAR source, as a since-cursor delta feed. Use when you mirror the calendar and need date changes and outcomes as they land, not a snapshot. Accuracy AND coverage are free at GET /v1/accuracy. Flat price per request."
    },
    "extensions": {
      "bazaar": {
        "info": {
          "input": {
            "type": "http",
            "method": "GET",
            "queryParams": {
              "limit": 100,
              "since": 0
            }
          },
          "output": {
            "type": "json",
            "example": {
              "data": [
                {
                  "ticker": "XSMPL",
                  "applied": true,
                  "company": "Sample Therapeutics, Inc.",
                  "outcome": null,
                  "tickers": [
                    "XSMPL",
                    "XPRTN"
                  ],
                  "event_id": 990101,
                  "filed_at": "2025-11-03",
                  "new_date": "2026-04-18",
                  "accession": "0009999001-25-000090",
                  "authority": "llm_high",
                  "drug_name": "SAMPLIMAB",
                  "confidence": "high",
                  "delta_days": null,
                  "event_type": "new_date_assigned",
                  "indication": "sample indication (moderate-to-severe examplitis)",
                  "prior_date": null,
                  "source_url": "https://www.sec.gov/Archives/edgar/data/9999001/000999900125000090/0009999001-25-000090-index.htm",
                  "catalyst_id": 990001,
                  "detected_at": "2025-11-03T13:41:09.000000+00:00",
                  "merged_into": null,
                  "date_changed": true,
                  "days_to_date": null,
                  "source_quote": "The FDA has assigned a PDUFA target action date of April 18, 2026 for SAMPLIMAB. [FICTIONAL SAMPLE — not a real filing sentence]",
                  "date_confidence": "confirmed",
                  "new_date_upcoming": false,
                  "application_number": "BLA999901"
                }
              ],
              "meta": {
                "limit": 100,
                "total": 1,
                "has_more": false,
                "next_since": 990106
              }
            }
          }
        },
        "schema": {
          "type": "object",
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "required": [
            "input"
          ],
          "properties": {
            "input": {
              "type": "object",
              "required": [
                "type",
                "method"
              ],
              "properties": {
                "type": {
                  "type": "string",
                  "const": "http"
                },
                "method": {
                  "enum": [
                    "GET",
                    "HEAD",
                    "DELETE"
                  ],
                  "type": "string"
                },
                "queryParams": {
                  "type": "object",
                  "required": [],
                  "properties": {
                    "limit": {
                      "type": "integer",
                      "default": 100,
                      "maximum": 500,
                      "minimum": 1,
                      "description": "Maximum number of events to return (1-500; default 100)."
                    },
                    "since": {
                      "type": "integer",
                      "minimum": 0,
                      "description": "Cursor: return only events with an event_id greater than this (0 = from the start). Pass the last event_id you saw to page forward."
                    },
                    "ticker": {
                      "type": "string",
                      "pattern": "^\\S+$",
                      "maxLength": 12,
                      "minLength": 1,
                      "description": "Optional server-side filter: only events whose record is filed by this ticker's issuer or exposes it as a co-filer in tickers[] (case-insensitive). Composes with since — limit counts matched events, so a filtered backlog drains without gaps. Unknown ticker returns an empty 200. Does not change the price."
                    }
                  }
                }
              },
              "additionalProperties": false
            },
            "output": {
              "type": "object",
              "required": [
                "type"
              ],
              "properties": {
                "type": {
                  "type": "string"
                },
                "example": {
                  "type": "object",
                  "properties": {
                    "data": {
                      "type": "array",
                      "items": {
                        "type": "object",
                        "required": [
                          "event_id",
                          "catalyst_id",
                          "event_type"
                        ],
                        "properties": {
                          "ticker": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "applied": {
                            "type": "boolean"
                          },
                          "company": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "outcome": {
                            "enum": [
                              "approved",
                              "tentative",
                              "crl",
                              "none_found",
                              null
                            ],
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "tickers": {
                            "type": "array",
                            "items": {
                              "type": "string"
                            }
                          },
                          "event_id": {
                            "type": "integer"
                          },
                          "filed_at": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "new_date": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "accession": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "authority": {
                            "enum": [
                              "human_lock",
                              "llm_high",
                              "regex",
                              "llm_medium",
                              "llm_low",
                              null
                            ],
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "drug_name": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "confidence": {
                            "enum": [
                              "high",
                              "medium",
                              "low",
                              null
                            ],
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "delta_days": {
                            "type": [
                              "integer",
                              "null"
                            ]
                          },
                          "event_type": {
                            "enum": [
                              "new_date_assigned",
                              "date_extension",
                              "decision_outcome",
                              "retracted",
                              "restored",
                              "corrected"
                            ],
                            "type": "string"
                          },
                          "indication": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "prior_date": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "source_url": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "catalyst_id": {
                            "type": "integer"
                          },
                          "detected_at": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "merged_into": {
                            "type": [
                              "integer",
                              "null"
                            ]
                          },
                          "date_changed": {
                            "type": "boolean"
                          },
                          "days_to_date": {
                            "type": [
                              "integer",
                              "null"
                            ]
                          },
                          "source_quote": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "date_confidence": {
                            "enum": [
                              "confirmed",
                              "reported",
                              "estimated",
                              null
                            ],
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "new_date_upcoming": {
                            "type": "boolean"
                          },
                          "application_number": {
                            "type": [
                              "string",
                              "null"
                            ]
                          }
                        }
                      },
                      "description": "One row per state change, oldest-first while draining a `since` cursor. `tickers` lists every co-filer exposed to the decision."
                    },
                    "meta": {
                      "type": "object",
                      "description": "Result metadata, e.g. total count."
                    }
                  }
                }
              }
            }
          }
        }
      }
    },
    "x402Version": 2
  },
  {
    "error": "Payment required",
    "accepts": [
      {
        "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
        "extra": {
          "name": "USD Coin",
          "version": "2"
        },
        "payTo": "0xcD8975137D48ED9bfD1C299a62c01420B860070d",
        "amount": "20000",
        "scheme": "exact",
        "network": "eip155:8453",
        "maxTimeoutSeconds": 300
      },
      {
        "asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
        "extra": {
          "feePayer": "Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"
        },
        "payTo": "3gM4YDDPAi7w1di7rHAAaHc5T1tR7NRXzLWzPPN4ZRaM",
        "amount": "20000",
        "scheme": "exact",
        "network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
        "maxTimeoutSeconds": 300
      }
    ],
    "resource": {
      "url": "https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming",
      "mimeType": "application/json",
      "description": "Upcoming FDA drug-approval (PDUFA) decision dates for US-listed biotechs — a forward catalyst calendar from primary SEC 8-K/6-K filings, every date grounded in a verbatim filing quote, cited to its EDGAR accession and later scored against the actual FDA decision. Use when you need the next 1-365 days of binary FDA events, whole feed or one ticker. Verify accuracy AND coverage free at GET /v1/accuracy before you pay. Flat price per request."
    },
    "extensions": {
      "bazaar": {
        "info": {
          "input": {
            "type": "http",
            "method": "GET",
            "queryParams": {
              "limit": 200,
              "within_days": 365
            }
          },
          "output": {
            "type": "json",
            "example": {
              "data": [
                {
                  "cik": "0009999001",
                  "stage": "set",
                  "ticker": "XSMPL",
                  "company": "Sample Therapeutics, Inc.",
                  "tickers": [
                    "XSMPL",
                    "XPRTN"
                  ],
                  "age_days": 12,
                  "authority": "llm_high",
                  "drug_name": "SAMPLIMAB",
                  "confidence": "high",
                  "indication": "sample indication (moderate-to-severe examplitis)",
                  "pdufa_date": "2026-11-15",
                  "source_url": "https://www.sec.gov/Archives/edgar/data/9999001/000999900126000001/0009999001-26-000001-index.htm",
                  "catalyst_id": 990001,
                  "last_updated": "2026-07-20T14:02:11.000000+00:00",
                  "source_quote": "The FDA has set a Prescription Drug User Fee Act (PDUFA) target action date of November 15, 2026 for SAMPLIMAB. [FICTIONAL SAMPLE — not a real filing sentence]",
                  "date_confidence": "confirmed",
                  "source_accession": "0009999001-26-000001",
                  "application_number": "BLA999901"
                }
              ],
              "meta": {
                "limit": 200,
                "total": 1,
                "has_more": null,
                "next_since": null
              }
            }
          }
        },
        "schema": {
          "type": "object",
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "required": [
            "input"
          ],
          "properties": {
            "input": {
              "type": "object",
              "required": [
                "type",
                "method"
              ],
              "properties": {
                "type": {
                  "type": "string",
                  "const": "http"
                },
                "method": {
                  "enum": [
                    "GET",
                    "HEAD",
                    "DELETE"
                  ],
                  "type": "string"
                },
                "queryParams": {
                  "type": "object",
                  "required": [],
                  "properties": {
                    "limit": {
                      "type": "integer",
                      "default": 200,
                      "maximum": 500,
                      "minimum": 1,
                      "description": "Maximum number of catalysts to return (1-500; default 200)."
                    },
                    "ticker": {
                      "type": "string",
                      "pattern": "^\\S+$",
                      "maxLength": 12,
                      "minLength": 1,
                      "description": "Optional server-side filter: only records filed by this ticker's issuer or exposing it as a co-filer in tickers[] (case-insensitive; the same membership the free /v1/coverage counts). Unknown ticker returns an empty 200. Omit for the whole feed. Does not change the price."
                    },
                    "within_days": {
                      "type": "integer",
                      "default": 365,
                      "maximum": 365,
                      "minimum": 1,
                      "description": "Only return catalysts whose PDUFA date falls within this many days from today (1-365; default 365)."
                    }
                  }
                }
              },
              "additionalProperties": false
            },
            "output": {
              "type": "object",
              "required": [
                "type"
              ],
              "properties": {
                "type": {
                  "type": "string"
                },
                "example": {
                  "type": "object",
                  "properties": {
                    "data": {
                      "type": "array",
                      "items": {
                        "type": "object",
                        "required": [
                          "catalyst_id",
                          "stage"
                        ],
                        "properties": {
                          "cik": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "stage": {
                            "enum": [
                              "set",
                              "extended",
                              "resolved",
                              "crl"
                            ],
                            "type": "string"
                          },
                          "ticker": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "company": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "tickers": {
                            "type": "array",
                            "items": {
                              "type": "string"
                            }
                          },
                          "age_days": {
                            "type": [
                              "integer",
                              "null"
                            ]
                          },
                          "authority": {
                            "enum": [
                              "human_lock",
                              "llm_high",
                              "regex",
                              "llm_medium",
                              "llm_low",
                              null
                            ],
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "drug_name": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "confidence": {
                            "enum": [
                              "high",
                              "medium",
                              "low",
                              null
                            ],
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "indication": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "pdufa_date": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "source_url": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "catalyst_id": {
                            "type": "integer"
                          },
                          "last_updated": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "source_quote": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "date_confidence": {
                            "enum": [
                              "confirmed",
                              "reported",
                              "estimated",
                              null
                            ],
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "source_accession": {
                            "type": [
                              "string",
                              "null"
                            ]
                          },
                          "application_number": {
                            "type": [
                              "string",
                              "null"
                            ]
                          }
                        }
                      },
                      "description": "One row per upcoming FDA decision. One decision is ONE row even when several public companies file on it (sponsor, originator, royalty holder) — filter on the `tickers` array, not the single `ticker`, or you will miss catalysts a partner is exposed to."
                    },
                    "meta": {
                      "type": "object",
                      "description": "Result metadata, e.g. total count."
                    }
                  }
                }
              }
            }
          }
        }
      }
    },
    "x402Version": 2
  }
]

OVER TIME

All charts use the 30d selector; each series spans only the dates it has data for. Every series is also served as JSON at /api/v1/services/biotech-catalyst-sentinel/price, /scores, /volume and /buyers. On-chain volume and distinct buyers are measured over the service's settlement address and are a conservative undercount (only settlements that reach a measured facilitator are counted). The on-chain series roll up hourly, so the latest day can be up to about an hour behind; distinct buyers are counted per payout address, so a service that settles to more than one address is an upper bound.

UPTIME

30d UPTIME 100%

RESPONSE TIME

AVG RESP 644ms

PRICE (captured 402, USD)

Median across 2 endpoints. Use the selector to isolate one.

SUB-SCORES (uptime + x402 compliance)

checklist grew 11->14 on 2026-07-28; a step here is a metric change, not a regression

PILLARS OVER TIME (measured)

price percentile in Data

site signals present (of 6)

Measured site and economics pillars from the assessment history, so the latest value shown elsewhere on this page reads as a point on a trend rather than a permanent state.

VOLUME (on-chain settlement, USD)

DISTINCT BUYERS

COMPLIANCE

14/14 checks pass · grade A

last 402 captured 2026-09-23 · last up 2026-09-25

402 payload captured
accepts[] array present
payTo address recoverable
payTo at accepts[0].payTo (conformant shape)
payTo is a valid on-chain address
atomic price declared
atomic price in a sane range
asset (token) address declared
network resolves to CAIP-2
payment scheme declared
served over HTTPS
declares the current x402 version (2)
EIP-712 domain parameters present on every EVM entry
x402 v2 envelope delivered in the payment-required header

SITE PILLARS

homepage reachable
openapi doc
pricing page
llms.txt
robots.txt
terms page

recent checks (18) live · click to expand

TIME STATUS RESP CAUSE

04:59:00 UTC ● OK 254ms

04:43:00 UTC ● OK 114ms

04:27:00 UTC ● OK 297ms

04:11:00 UTC ● OK 281ms

03:55:01 UTC ● OK 465ms

03:39:00 UTC ● OK 143ms

03:23:00 UTC ● OK 142ms

03:07:01 UTC ● OK 721ms

02:51:01 UTC ● OK 647ms

02:35:01 UTC ● OK 776ms

02:19:00 UTC ● OK 380ms

02:03:00 UTC ● OK 261ms

01:47:00 UTC ● OK 295ms

01:31:01 UTC ● OK 710ms

01:15:00 UTC ● OK 93ms

00:59:02 UTC ● OK 856ms

00:43:00 UTC ● OK 72ms

00:27:00 UTC ● OK 134ms

EMBED THIS BADGE

Show that Biotech Catalyst Sentinel is monitored on x402-list. Paste this on your site or README, it links back to this live listing.

status

Biotech Catalyst Sentinel uptime on x402-list — live uptime

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// HTML · live uptime variant

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  <img src="https://x402-list.com/badge/biotech-catalyst-sentinel.svg?data=uptime" alt="Biotech Catalyst Sentinel uptime on x402-list" height="28">
</a>

RUN THIS SERVICE?

Keep this listing accurate: propose changes to the name, description, website, category or add new endpoints to monitor. Ownership is verified with a domain proof and every change is reviewed manually; measured data stays read-only.

[ update this listing ]

Earn the verified tier: x402list pays a real call to this endpoint and, if it delivers, the service is delivery-verified. The fee covers the cost of the probe, not the badge; there is no refund if the call does not deliver. Agent and API only, no in-browser signing. See /api.

[ verify this service ($0.25) ]

To request delisting, email info@x402-list.com or update your listing at /services/biotech-catalyst-sentinel/update.