x402 List

x402 Protocol Service Directory

Biotech Catalyst Sentinel

Data ✓ VERIFIED

verified until 2026-08-17

Upcoming FDA PDUFA decision dates for US-listed biotechs, extracted from primary SEC 8-K/6-K filings (classify-before-extract, source-quote-grounded). Date accuracy is independently backtested — median 1-day error. Verify the accuracy proof FREE at /v1/accuracy before paying. $0.02/call, USDC on Base or Solana.

Pay from $0.02 per request in USDC on Base / Solana, settled onchain via the x402 protocol, no signup, no API key needed.

first settlement 2026-06-23 · $0.36 all-time · settled via coinbase

BASE URL https://api.biotechcatalystsentinel.com WEBSITE https://biotechcatalystsentinel.com ENDPOINTS 1 NETWORK Base / Solana ASSET USDC MEMBER SINCE 2026-06-25 MONITORED SINCE 2026-06-25

ASSESSMENT

updated 11m ago

Evidence-backed signals, not a single score. Click any chip for the proof. Measured values stay read-only; unknown is honest.

reliability 100%
uptime 24h
100%
uptime 7d
100%
uptime 30d
100%
uptime 90d
100%
response p95
1484ms
avg response
674ms
total checks
2,775

Measured on the unpaid 402 handshake, not the paid call. A service can 402 correctly and still fail after payment.

compliance A (14/14)

14 of 14 x402 conformance checks pass. Full checklist below.

jump to compliance checklist

price $0.02 (p67 in Data)
price (min)
$0.02
category percentile (min)
p67 in Data
endpoints / prices
1 / 1
model
flat
stability
100%
risk clean

No deterministic risk flag. Risk fires only on an exact blocklist match, or a reserved-brand name with a mismatched verified payTo. Never from low uptime, a high price, or a model guess.

domain age
-
registrar
-
hosting
custom
domain created
---

Identity facts, not a risk score.

traction $0.24 30d · 5 buyers
volume 30d
$0.24
buyers 30d
5
settlements 30d
9
first settlement
2026-06-23
last settlement
2026-08-07
top buyer share
67% of 30d volume
trend 7d vs 30d
0.36x the 30d daily rate
networks
eip155:8453, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdpKuc147dw2N9d
volume all-time
$0.36
settlements all-time
15
median settlement 30d
$0.02
max settlement 30d
$0.05
settled via
coinbase

Conservative undercount: only USDC settlements via facilitators we measure are counted. A measured floor, not an estimate.

Top buyer share is a concentration signal, not part of the ranking score.

CHANGES

10 events, detecting since 2026-07-24

Payout, price, and schema changes detected on this service's x402 wire. A payout rotation at an unchanged price shows up here even when nothing else moves. Full feed at /changes.

changes schema changed 1h ago (10 since 2026-07-24)

schema changed · 1h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}

schema changed · 2h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}

schema changed · 4h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}

schema changed · 8h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}

schema changed · 11h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema changed · 13h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}

schema changed · 14h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema changed · 15h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}

schema changed · 36h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}

schema changed · 38h ago

schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}

schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}

see all changes for this service

WHAT IT DOES

ai-derived

No AI synthesis has been produced for this service yet.

ENDPOINTS

Service endpoints with HTTP method, path, description, pricing, and network
METHOD PATH DESCRIPTION PRICE NETWORK ASSET 402 CHANNEL
GET /v1/catalysts/upcoming $0.02 Base/Solana USDC header
1 endpoints

REQUEST / RESPONSE EXAMPLE

An unpaid request to GET /v1/catalysts/upcoming returns HTTP 402 with the payment terms. Settle onchain via your facilitator, then retry with the X-Payment header.

// request
curl -i 'https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming'
// 402 response (captured by monitor) · 1 payload · click to expand
[
  {
    "error": "Payment required",
    "accepts": [
      {
        "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
        "extra": {
          "name": "USD Coin",
          "version": "2"
        },
        "payTo": "0xcD8975137D48ED9bfD1C299a62c01420B860070d",
        "amount": "20000",
        "scheme": "exact",
        "network": "eip155:8453",
        "maxTimeoutSeconds": 300
      },
      {
        "asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
        "extra": {
          "feePayer": "GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"
        },
        "payTo": "3gM4YDDPAi7w1di7rHAAaHc5T1tR7NRXzLWzPPN4ZRaM",
        "amount": "20000",
        "scheme": "exact",
        "network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
        "maxTimeoutSeconds": 300
      }
    ],
    "resource": {
      "url": "https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming",
      "mimeType": "application/json",
      "description": "Upcoming FDA drug-approval (PDUFA) decision dates for US-listed biotechs — a forward catalyst calendar extracted from primary SEC 8-K/6-K filings, every date grounded in a verbatim filing quote and cited to its EDGAR accession. The difference from other catalyst feeds: each date is scored against the actual FDA decision, so accuracy is a public, auditable track record (median 1-day error) — verify it free at GET /v1/accuracy before you pay."
    },
    "extensions": {
      "bazaar": {
        "info": {
          "input": {
            "type": "http",
            "method": "GET",
            "queryParams": {
              "limit": 200,
              "within_days": 365
            }
          },
          "output": {
            "type": "json",
            "example": {
              "data": [
                {
                  "stage": "set",
                  "ticker": "OTLK",
                  "company": "Outlook Therapeutics, Inc.",
                  "tickers": [
                    "OTLK"
                  ],
                  "drug_name": "ONS-5010/LYTENAVA (bevacizumab-vikg)",
                  "confidence": "high",
                  "indication": "wet AMD",
                  "pdufa_date": "2026-07-29",
                  "source_url": "https://www.sec.gov/Archives/edgar/data/1649989/..."
                }
              ],
              "meta": {
                "total": 1
              }
            }
          }
        },
        "schema": {
          "type": "object",
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "required": [
            "input"
          ],
          "properties": {
            "input": {
              "type": "object",
              "required": [
                "type",
                "method"
              ],
              "properties": {
                "type": {
                  "type": "string",
                  "const": "http"
                },
                "method": {
                  "enum": [
                    "GET",
                    "HEAD",
                    "DELETE"
                  ],
                  "type": "string"
                },
                "queryParams": {
                  "type": "object",
                  "properties": {
                    "limit": {
                      "type": "integer",
                      "maximum": 500,
                      "minimum": 1,
                      "description": "Maximum number of catalysts to return (1-500; default 200)."
                    },
                    "within_days": {
                      "type": "integer",
                      "maximum": 365,
                      "minimum": 1,
                      "description": "Only return catalysts whose PDUFA date falls within this many days from today (1-365; default 365)."
                    }
                  }
                }
              },
              "additionalProperties": false
            },
            "output": {
              "type": "object",
              "required": [
                "type"
              ],
              "properties": {
                "type": {
                  "type": "string"
                },
                "example": {
                  "type": "object",
                  "properties": {
                    "data": {
                      "type": "array",
                      "items": {
                        "type": "object"
                      },
                      "description": "One row per upcoming FDA decision: drug_name, company, ticker, tickers, indication, pdufa_date, stage, confidence, source_url. One decision is ONE row even when several public companies file on it (sponsor, originator, royalty holder) — filter on the `tickers` array, not the single `ticker`, or you will miss catalysts a partner is exposed to."
                    },
                    "meta": {
                      "type": "object",
                      "description": "Result metadata, e.g. total count."
                    },
                    "error": {
                      "type": [
                        "string",
                        "null"
                      ],
                      "description": "Error string, or null."
                    }
                  }
                }
              }
            }
          }
        }
      }
    },
    "x402Version": 2
  }
]

OVER TIME

All charts use the 30d selector; each series spans only the dates it has data for. Every series is also served as JSON at /api/v1/services/biotech-catalyst-sentinel/price, /scores, /volume and /buyers. On-chain volume and distinct buyers are measured over the service's settlement address and are a conservative undercount (only settlements that reach a measured facilitator are counted). The on-chain series roll up hourly, so the latest day can be up to about an hour behind; distinct buyers are counted per payout address, so a service that settles to more than one address is an upper bound.

UPTIME
07-12 · uptime 100.0% · 375ms avg07-13 · uptime 100.0% · 597ms avg07-14 · uptime 100.0% · 526ms avg07-15 · uptime 100.0% · 863ms avg07-16 · uptime 100.0% · 857ms avg07-17 · uptime 100.0% · 567ms avg07-18 · uptime 100.0% · 424ms avg07-19 · uptime 100.0% · 365ms avg07-20 · uptime 100.0% · 503ms avg07-21 · uptime 100.0% · 525ms avg07-22 · uptime 100.0% · 342ms avg07-23 · uptime 100.0% · 220ms avg07-24 · uptime 100.0% · 388ms avg07-25 · uptime 100.0% · 769ms avg07-26 · uptime 100.0% · 743ms avg07-27 · uptime 100.0% · 920ms avg07-28 · uptime 100.0% · 888ms avg07-29 · uptime 100.0% · 645ms avg07-30 · uptime 100.0% · 720ms avg07-31 · uptime 100.0% · 806ms avg08-01 · uptime 100.0% · 1020ms avg08-02 · uptime 100.0% · 841ms avg08-03 · uptime 100.0% · 1051ms avg08-04 · uptime 100.0% · 815ms avg08-05 · uptime 100.0% · 1122ms avg08-06 · uptime 100.0% · 760ms avg08-07 · uptime 100.0% · 566ms avg08-08 · uptime 100.0% · 626ms avg08-09 · uptime 100.0% · 824ms avg08-10 · uptime 100.0% · 747ms avg07-1208-10
30d UPTIME 100%
RESPONSE TIME
07-12 · 375ms avg07-12 · 375ms avg07-13 · 597ms avg07-13 · 597ms avg07-14 · 526ms avg07-14 · 526ms avg07-15 · 863ms avg07-15 · 863ms avg07-16 · 857ms avg07-16 · 857ms avg07-17 · 567ms avg07-17 · 567ms avg07-18 · 424ms avg07-18 · 424ms avg07-19 · 365ms avg07-19 · 365ms avg07-20 · 503ms avg07-20 · 503ms avg07-21 · 525ms avg07-21 · 525ms avg07-22 · 342ms avg07-22 · 342ms avg07-23 · 220ms avg07-23 · 220ms avg07-24 · 388ms avg07-24 · 388ms avg07-25 · 769ms avg07-25 · 769ms avg07-26 · 743ms avg07-26 · 743ms avg07-27 · 920ms avg07-27 · 920ms avg07-28 · 888ms avg07-28 · 888ms avg07-29 · 645ms avg07-29 · 645ms avg07-30 · 720ms avg07-30 · 720ms avg07-31 · 806ms avg07-31 · 806ms avg08-01 · 1020ms avg08-01 · 1020ms avg08-02 · 841ms avg08-02 · 841ms avg08-03 · 1051ms avg08-03 · 1051ms avg08-04 · 815ms avg08-04 · 815ms avg08-05 · 1122ms avg08-05 · 1122ms avg08-06 · 760ms avg08-06 · 760ms avg08-07 · 566ms avg08-07 · 566ms avg08-08 · 626ms avg08-08 · 626ms avg08-09 · 824ms avg08-09 · 824ms avg08-10 · 747ms avg08-10 · 747ms avg07-1208-10
AVG RESP 674ms
PRICE (captured 402, USD)
07-11 · $0.0208-10 · $0.02$0.0207-1108-10
SUB-SCORES (uptime + x402 compliance)
07-13 uptime: 100.0% compliance: 92% checks07-14 uptime: 100.0% compliance: 92% checks07-15 uptime: 100.0% compliance: 92% checks07-16 uptime: 100.0% compliance: 92% checks07-17 uptime: 100.0% compliance: 100% checks07-18 uptime: 100.0% compliance: 100% checks07-19 uptime: 100.0% compliance: 100% checks07-20 uptime: 100.0% compliance: 100% checks07-21 uptime: 100.0% compliance: 100% checks07-22 uptime: 100.0% compliance: 100% checks07-23 uptime: 100.0% compliance: 100% checks07-24 uptime: 100.0% compliance: 100% checks07-25 uptime: 100.0% compliance: 100% checks07-26 uptime: 100.0% compliance: 100% checks07-27 uptime: 100.0% compliance: 100% checks07-28 uptime: 100.0% compliance: 100% checks07-29 uptime: 100.0% compliance: 100% checks07-30 uptime: 100.0% compliance: 100% checks07-31 uptime: 100.0% compliance: 100% checks08-01 uptime: 100.0% compliance: 100% checks08-02 uptime: 100.0% compliance: 100% checks08-03 uptime: 100.0% compliance: 100% checks08-04 uptime: 100.0% compliance: 100% checks08-05 uptime: 100.0% compliance: 100% checks08-06 uptime: 100.0% compliance: 100% checks08-07 uptime: 100.0% compliance: 100% checks08-08 uptime: 100.0% compliance: 100% checks08-09 uptime: 100.0% compliance: 100% checks08-10 uptime: 100.0% compliance: 100% checksuptimecompliance07-1308-10

checklist grew 11->14 on 2026-07-28; a step here is a metric change, not a regression

PILLARS OVER TIME (measured)

Measured site and economics pillars from the assessment history, so the latest value shown elsewhere on this page reads as a point on a trend rather than a permanent state.

VOLUME (on-chain settlement, USD)
07-16 · $0.1807-26 · $0.0207-28 · $0.0208-07 · $0.02peak $0.1807-1608-07
DISTINCT BUYERS
07-16 · 2 buyers07-26 · 1 buyer07-28 · 1 buyer08-07 · 1 buyerpeak 2 buyers07-1608-07

COMPLIANCE

14/14 checks pass · grade A

last 402 captured 2026-08-10 · last up 2026-08-10

  • 402 payload captured
  • accepts[] array present
  • payTo address recoverable
  • payTo at accepts[0].payTo (conformant shape)
  • payTo is a valid on-chain address
  • atomic price declared
  • atomic price in a sane range
  • asset (token) address declared
  • network resolves to CAIP-2
  • payment scheme declared
  • served over HTTPS
  • declares the current x402 version (2)
  • EIP-712 domain parameters present on every EVM entry
  • x402 v2 envelope delivered in the payment-required header

SITE PILLARS

  • homepage reachable
  • openapi doc
  • pricing page
  • llms.txt
  • robots.txt
  • terms page
recent checks (18) live · click to expand
TIME STATUS RESP CAUSE
● SLOW 1709ms
● OK 803ms
● OK 135ms
● SLOW 1769ms
● SLOW 1272ms
● OK 525ms
● SLOW 2004ms
● OK 676ms
● OK 670ms
● OK 897ms
● OK 506ms
● SLOW 1301ms
● OK 840ms
● SLOW 1198ms
● OK 947ms
● OK 422ms
● OK 788ms
● OK 849ms

EMBED THIS BADGE

Show that Biotech Catalyst Sentinel is monitored on x402-list. Paste this on your site or README, it links back to this live listing.

Biotech Catalyst Sentinel listed on x402-list
status
Biotech Catalyst Sentinel uptime on x402-list
live uptime
// HTML
<a href="https://x402-list.com/services/biotech-catalyst-sentinel?utm_source=badge&utm_medium=referral&utm_campaign=embed">
  <img src="https://x402-list.com/badge/biotech-catalyst-sentinel.svg" alt="Biotech Catalyst Sentinel listed on x402-list" height="28">
</a>
// Markdown
[![Biotech Catalyst Sentinel on x402-list](https://x402-list.com/badge/biotech-catalyst-sentinel.svg)](https://x402-list.com/services/biotech-catalyst-sentinel?utm_source=badge&utm_medium=referral&utm_campaign=embed)
// HTML · live uptime variant
<a href="https://x402-list.com/services/biotech-catalyst-sentinel?utm_source=badge&utm_medium=referral&utm_campaign=embed">
  <img src="https://x402-list.com/badge/biotech-catalyst-sentinel.svg?data=uptime" alt="Biotech Catalyst Sentinel uptime on x402-list" height="28">
</a>

RUN THIS SERVICE?

Keep this listing accurate: propose changes to the name, description, website, category or add new endpoints to monitor. Ownership is verified with a domain proof and every change is reviewed manually; measured data stays read-only.

[ update this listing ]

To request delisting, email [email protected] or update your listing at /services/biotech-catalyst-sentinel/update.