verified until 2026-08-17
Upcoming FDA PDUFA decision dates for US-listed biotechs, extracted from primary SEC 8-K/6-K filings (classify-before-extract, source-quote-grounded). Date accuracy is independently backtested — median 1-day error. Verify the accuracy proof FREE at /v1/accuracy before paying. $0.02/call, USDC on Base or Solana.
Pay from $0.02 per request in USDC on Base / Solana, settled onchain via the x402 protocol, no signup, no API key needed.
first settlement 2026-06-23 · $0.36 all-time · settled via coinbase
ASSESSMENT
updated 11m agoEvidence-backed signals, not a single score. Click any chip for the proof. Measured values stay read-only; unknown is honest.
reliability 100%
- uptime 24h
- 100%
- uptime 7d
- 100%
- uptime 30d
- 100%
- uptime 90d
- 100%
- response p95
- 1484ms
- avg response
- 674ms
- total checks
- 2,775
Measured on the unpaid 402 handshake, not the paid call. A service can 402 correctly and still fail after payment.
compliance A (14/14)
14 of 14 x402 conformance checks pass. Full checklist below.
price $0.02 (p67 in Data)
- price (min)
- $0.02
- category percentile (min)
- p67 in Data
- endpoints / prices
- 1 / 1
- model
- flat
- stability
- 100%
risk clean
No deterministic risk flag. Risk fires only on an exact blocklist match, or a reserved-brand name with a mismatched verified payTo. Never from low uptime, a high price, or a model guess.
- domain age
- -
- registrar
- -
- hosting
- custom
- domain created
- ---
Identity facts, not a risk score.
traction $0.24 30d · 5 buyers
- volume 30d
- $0.24
- buyers 30d
- 5
- settlements 30d
- 9
- first settlement
- 2026-06-23
- last settlement
- 2026-08-07
- top buyer share
- 67% of 30d volume
- trend 7d vs 30d
- 0.36x the 30d daily rate
- networks
- eip155:8453, solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdpKuc147dw2N9d
- volume all-time
- $0.36
- settlements all-time
- 15
- median settlement 30d
- $0.02
- max settlement 30d
- $0.05
- settled via
- coinbase
Conservative undercount: only USDC settlements via facilitators we measure are counted. A measured floor, not an estimate.
Top buyer share is a concentration signal, not part of the ranking score.
CHANGES
10 events, detecting since 2026-07-24Payout, price, and schema changes detected on this service's x402 wire. A payout rotation at an unchanged price shows up here even when nothing else moves. Full feed at /changes.
changes schema changed 1h ago (10 since 2026-07-24)
schema changed · 1h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema changed · 2h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"}
schema changed · 4h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema changed · 8h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}
schema changed · 11h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema changed · 13h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}
schema changed · 14h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema changed · 15h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"}
schema changed · 36h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}
schema changed · 38h ago
schema removed GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BFK9TLC3edb13K6v4YyH3DwPb5DSUpkWvb7XnqCL9b4F"}
schema added GET /v1/catalysts/upcoming exact solana:5eykt4usfv8p8njdtrepy1vzqkqzkvdp EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v USDC 2 300 {"feePayer":"BENrLoUbndxoNMUS5JXApGMtNykLjFXXixMtpDwDR9SP"}
WHAT IT DOES
ai-derivedNo AI synthesis has been produced for this service yet.
ENDPOINTS
| METHOD | PATH | DESCRIPTION | PRICE | NETWORK | ASSET | 402 CHANNEL |
|---|---|---|---|---|---|---|
| GET | /v1/catalysts/upcoming | $0.02 | Base/Solana | USDC | header |
REQUEST / RESPONSE EXAMPLE
An unpaid request to GET /v1/catalysts/upcoming returns HTTP 402 with the payment terms. Settle onchain via your facilitator, then retry with the X-Payment header.
curl -i 'https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming'
// 402 response (captured by monitor) · 1 payload · click to expand
[
{
"error": "Payment required",
"accepts": [
{
"asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
"extra": {
"name": "USD Coin",
"version": "2"
},
"payTo": "0xcD8975137D48ED9bfD1C299a62c01420B860070d",
"amount": "20000",
"scheme": "exact",
"network": "eip155:8453",
"maxTimeoutSeconds": 300
},
{
"asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
"extra": {
"feePayer": "GVJJ7rdGiXr5xaYbRwRbjfaJL7fmwRygFi1H6aGqDveb"
},
"payTo": "3gM4YDDPAi7w1di7rHAAaHc5T1tR7NRXzLWzPPN4ZRaM",
"amount": "20000",
"scheme": "exact",
"network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
"maxTimeoutSeconds": 300
}
],
"resource": {
"url": "https://api.biotechcatalystsentinel.com/v1/catalysts/upcoming",
"mimeType": "application/json",
"description": "Upcoming FDA drug-approval (PDUFA) decision dates for US-listed biotechs — a forward catalyst calendar extracted from primary SEC 8-K/6-K filings, every date grounded in a verbatim filing quote and cited to its EDGAR accession. The difference from other catalyst feeds: each date is scored against the actual FDA decision, so accuracy is a public, auditable track record (median 1-day error) — verify it free at GET /v1/accuracy before you pay."
},
"extensions": {
"bazaar": {
"info": {
"input": {
"type": "http",
"method": "GET",
"queryParams": {
"limit": 200,
"within_days": 365
}
},
"output": {
"type": "json",
"example": {
"data": [
{
"stage": "set",
"ticker": "OTLK",
"company": "Outlook Therapeutics, Inc.",
"tickers": [
"OTLK"
],
"drug_name": "ONS-5010/LYTENAVA (bevacizumab-vikg)",
"confidence": "high",
"indication": "wet AMD",
"pdufa_date": "2026-07-29",
"source_url": "https://www.sec.gov/Archives/edgar/data/1649989/..."
}
],
"meta": {
"total": 1
}
}
}
},
"schema": {
"type": "object",
"$schema": "https://json-schema.org/draft/2020-12/schema",
"required": [
"input"
],
"properties": {
"input": {
"type": "object",
"required": [
"type",
"method"
],
"properties": {
"type": {
"type": "string",
"const": "http"
},
"method": {
"enum": [
"GET",
"HEAD",
"DELETE"
],
"type": "string"
},
"queryParams": {
"type": "object",
"properties": {
"limit": {
"type": "integer",
"maximum": 500,
"minimum": 1,
"description": "Maximum number of catalysts to return (1-500; default 200)."
},
"within_days": {
"type": "integer",
"maximum": 365,
"minimum": 1,
"description": "Only return catalysts whose PDUFA date falls within this many days from today (1-365; default 365)."
}
}
}
},
"additionalProperties": false
},
"output": {
"type": "object",
"required": [
"type"
],
"properties": {
"type": {
"type": "string"
},
"example": {
"type": "object",
"properties": {
"data": {
"type": "array",
"items": {
"type": "object"
},
"description": "One row per upcoming FDA decision: drug_name, company, ticker, tickers, indication, pdufa_date, stage, confidence, source_url. One decision is ONE row even when several public companies file on it (sponsor, originator, royalty holder) — filter on the `tickers` array, not the single `ticker`, or you will miss catalysts a partner is exposed to."
},
"meta": {
"type": "object",
"description": "Result metadata, e.g. total count."
},
"error": {
"type": [
"string",
"null"
],
"description": "Error string, or null."
}
}
}
}
}
}
}
}
},
"x402Version": 2
}
] OVER TIME
All charts use the 30d selector; each series spans only the dates it has data for. Every series is also served as JSON at /api/v1/services/biotech-catalyst-sentinel/price, /scores, /volume and /buyers. On-chain volume and distinct buyers are measured over the service's settlement address and are a conservative undercount (only settlements that reach a measured facilitator are counted). The on-chain series roll up hourly, so the latest day can be up to about an hour behind; distinct buyers are counted per payout address, so a service that settles to more than one address is an upper bound.
checklist grew 11->14 on 2026-07-28; a step here is a metric change, not a regression
Measured site and economics pillars from the assessment history, so the latest value shown elsewhere on this page reads as a point on a trend rather than a permanent state.
COMPLIANCE
14/14 checks pass · grade Alast 402 captured 2026-08-10 · last up 2026-08-10
- 402 payload captured
- accepts[] array present
- payTo address recoverable
- payTo at accepts[0].payTo (conformant shape)
- payTo is a valid on-chain address
- atomic price declared
- atomic price in a sane range
- asset (token) address declared
- network resolves to CAIP-2
- payment scheme declared
- served over HTTPS
- declares the current x402 version (2)
- EIP-712 domain parameters present on every EVM entry
- x402 v2 envelope delivered in the payment-required header
SITE PILLARS
- homepage reachable
- openapi doc
- pricing page
- llms.txt
- robots.txt
- terms page
recent checks (18) live · click to expand
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